参考文献:(上下滑动查看更多)
[1]中华医学会肝病学分会.肝硬化诊治指南[J]. 中华肝脏病杂志, 2019, 27(11): 846-865. DOI: 10.3760/cma.j.issn.1007-3418.2019.11.008.
[2]FriedLP, TangenCM, WalstonJ, et al. Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M156. DOI: 10.1093/gerona/56.3.m146.
[3]WuC, SmitE, XueQL, et al. Prevalence and correlates of frailty among community-dwelling chinese older adults: the china gealth and retirement jongitudinal study[J]. J Gerontol A Biol Sci Med Sci, 2017, 73(1): 102-108. DOI: 10.1093/gerona/glx098.
[4]CesariM, Araujo De CarvalhoI, Amuthavalli ThiyagarajanJ, et al. Evidence for the domains supporting the construct of intrinsic capacity[J]. J Gerontol A Biol Sci Med Sci, 2018, 73(12): 1653-1660. DOI: 10.1093/gerona/gly011.
[5]YuR, Amuthavalli ThiyagarajanJ, LeungJ, et al. Validation of the construct of intrinsic capacity in a longitudinal chinese cohort[J]. J Nutr Health Aging, 2021, 25(6): 808-815. DOI: 10.1007/s12603-021-1637-z.
[6]Pérez-RosP, Vila-CandelR, López-HernándezL, et al. Nutritional status and risk factors for frailty in community-dwelling older people: a cross-sectional study[J]. Nutrients, 2020, 12(4): 1041. DOI: 10.3390/nu12041041.
[7]MaL, TangZ, ZhangL, et al. Prevalence of Frailty and Associated factors in the community-dwelling population of china[J]. J Am Geriatr Soc, 2018, 66(3): 559-564. DOI: 10.1111/jgs.15214.
[8]InglésM, Mas-BarguesC, Gimeno-MallenchL, et al. Relation between genetic factors and frailty in older adults[J]. J Am Med Dir Assoc, 2019.20(11): 1451-1457. DOI: 10.1016/j.jamda.2019.03.011.
[9]FengZ, LugtenbergM, FranseC, et al. Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies[J]. PLoS One, 2017, 12(6): e0178383. DOI: 10.1371/journal.pone.0178383.
[10]Pérez-TasigchanaRF, León-MuñozLM, Lopez-GarciaE, et al. Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study[J]. Age Ageing, 2017, 46(5): 807-812. DOI: 10.1093/ageing/afx023.
[11]TraubJ, ReissL, AliwaB, et al. Malnutrition in patients with liver cirrhosis[J]. Nutrients, 2021, 13(2): 540. DOI: 10.3390/nu13020540.
[12]TandonP, RamanM, MourtzakisM, et al. A practical approach to nutritional screening and assessment in cirrhosis[J]. Hepatology, 2017, 65(3): 1044-1057. DOI: 10.1002/hep.29003.
[13]DasarathyS, MerliM. Sarcopenia from mechanism to diagnosis and treatment in liver disease[J]. J Hepatol, 2016, 65(6): 1232-1244. DOI: 10.1016/j.jhep.2016.07.040.
[14]LaiJC, TandonP, BernalW, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the american association for the study of liver diseases[J]. Hepatology, 2021.74(3): 1611-1644. DOI: 10.1002/hep.32049.
[15]EASL Clinical Practice Guidelines on nutrition in chronic liver disease[J]. J Hepatol, 2019, 70(1): 172-193. DOI: 10.1016/j.jhep.2018.06.024.
[16]AbramsGD, FeldmanD, SafranMR. Effects of vitamin D on skeletal muscle and athletic performance[J]. J Am Acad Orthop Surg, 2018, 26(8): 278-285. DOI: 10.5435/jaaos-d-16-00464.
[17]NishikawaH, AsaiA, FukunishiS. The significance of zinc in patients with chronic liver disease[J]. Nutrients, 2022, 14(22): 4855. DOI: 10.3390/nu14224855.
[18]NishikawaH, YohK, EnomotoH, et al. Serum zinc level is associated with frailty in chronic liver diseases[J]. J Clin Med, 2020, 9(5): 1570. DOI: 10.3390/jcm9051570.
[19]KoyamaY, BrennerDA. Liver inflammation and fibrosis[J]. J Clin Invest, 2017.127(1): 55-64. DOI: 10.1172/jci88881.
[20]DalleS, RossmeislovaL, KoppoK. The role of inflammation in age-related sarcopenia[J]. Front Physiol, 2017, 8: 1045. DOI: 10.3389/fphys.2017.01045.
[21]WangX, WuM. Research progress of gut microbiota and frailty syndrome[J]. Open Med (Wars), 2021, 16(1): 1525-1536. DOI: 10.1515/med-2021-0364.
[22]PansarasaO, PistonoC, DavinA, et al. Altered immune system in frailty: Genetics and diet may influence inflammation[J]. Ageing Res Rev, 2019, 54: 100935. DOI: 10.1016/j.arr.2019.100935.
[23]MirR, JhaCK, KhullarN, et al. On the role of inflammatory and cytokine biomarkers in the pathogenesis of frailty syndrome[J]. Endocr Metab Immune Disord Drug Targets, 2022, 22(14): 1357-1366. DOI: 10.2174/1871530322666220304220522.
[24]SinghS, TanejaS, TandonP, et al. High prevalence of hormonal changes and hepatic osteodystrophy in frail patients with cirrhosis-an observational study[J]. J Clin Exp Hepatol, 2022, 12(3): 800-807. DOI: 10.1016/j.jceh.2021.11.012.
[25]CleggA, Hassan-SmithZ. Frailty and the endocrine system[J]. Lancet Diabetes Endocrinol, 2018, 6(9): 743-752. DOI: 10.1016/s2213-8587(18)30110-4.
[26]DandonaP, DhindsaS, GhanimH, et al. Mechanisms underlying the metabolic actions of testosterone in humans: a narrative review[J]. Diabetes Obes Metab, 2021, 23(1): 18-28. DOI: 10.1111/dom.14206.
[27]TranahTH, BallesterMP, Carbonell-AsinsJA, et al. Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis[J]. J Hepatol, 2022, 77(6): 1554-1563. DOI: 10.1016/j.jhep.2022.07.014.
[28]DasarathyS, HatzoglouM. Hyperammonemia and proteostasis in cirrhosis[J]. Curr Opin Clin Nutr Metab Care, 2018, 21(1): 30-36. DOI: 10.1097/mco.0000000000000426.
[29]KumarA, DavuluriG, SilvaRNE, et al. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis[J]. Hepatology, 2017, 65(6): 2045-2058. DOI: 10.1002/hep.29107.
[30]KumarA, DavuluriG, WelchN, et al. Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy[J]. Free Radic Biol Med, 2019, 145: 284-299. DOI: 10.1016/j.freeradbiomed.2019.09.031.
[31]LaiJC, GangerDR, VolkML, et al. Association of frailty and sex with wait list mortality in liver transplant candidates in the multicenter functional assessment in liver transplantation (FrAILT) study[J]. JAMA Surg, 2021, 156(3): 256-262. DOI: 10.1001/jamasurg.2020.5674.
[32]DoniniLM, BusettoL, BischoffSC, et al. Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO Consensus Statement[J]. Obes Facts, 2022, 15(3): 321-335. DOI: 10.1159/000521241.
[33]ShuW, ShanjianC, JinpiaoL, et al. Gut microbiota dysbiosis in patients with hepatitis B virus-related cirrhosis[J]. Ann Hepatol, 2022, 27(2): 100676. DOI: 10.1016/j.aohep.2022.100676.
[34]PhilipsCA, AugustineP. Gut barrier and microbiota in cirrhosis[J]. J Clin Exp Hepatol, 2022, 12(2): 625-638. DOI: 10.1016/j.jceh.2021.08.027.
[35]LiuY, JinY, LiJ, et al. Small bowel transit and altered gut microbiota in patients with liver cirrhosis[J]. Front Physiol, 2018, 9: 470. DOI: 10.3389/fphys.2018.00470.
[36]TicinesiA, MilaniC, LauretaniF, et al. Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients[J]. Sci Rep, 2017, 7(1): 11102. DOI: 10.1038/s41598-017-10734-y.
[37]JacksonMA, JefferyIB, BeaumontM, et al. Signatures of early frailty in the gut microbiota[J]. Genome Med, 2016, 8(1): 8. DOI: 10.1186/s13073-016-0262-7.
[38]WilliamsFR, BerzigottiA, LordJM, et al. Review article: impact of exercise on physical frailty in patients with chronic liver disease[J]. Aliment Pharmacol Ther, 2019, 50(9): 988-1000. DOI: 10.1111/apt.15491.
[39]CarteeGD, HeppleRT, BammanMM, et al. Exercise promotes healthy aging of skeletal muscle[J]. Cell Metab, 2016, 23(6): 1034-1047. DOI: 10.1016/j.cmet.2016.05.007.
[40]ShresthaD, RathiS, GroverS, et al. Factors affecting psychological burden on the informal caregiver of patients with cirrhosis: looking beyond the patient[J]. J Clin Exp Hepatol, 2020, 10(1): 9-16. DOI: 10.1016/j.jceh.2019.06.002.
[41]BittermannT, DwinnellsK, ChadhaS, et al. Low health literacy is associated with frailty and reduced likelihood of liver transplant listing: a prospective cohort study[J]. Liver Transpl, 2020.26(11): 1409-1421. DOI: 10.1002/lt.25830.
[42]CronDC, FriedmanJF, WinderGS, et al. Depression and frailty in patients with end-stage liver disease referred for transplant evaluation[J]. Am J Transplant, 2016, 16(6): 1805-1811. DOI: 10.1111/ajt.13639.
[43]TandonP, TangriN, ThomasL, et al. A rapid bedside screen to predict unplanned hospitalization and death in outpatients with cirrhosis: a prospective evaluation of the clinical frailty scale[J]. Am J Gastroenterol, 2016, 111(12): 1759-1767. DOI: 10.1038/ajg.2016.303.
[44]SerperM, TaoSY, KentDS, et al. Inpatient frailty assessment is feasible and predicts nonhome discharge and mortality in decompensated cirrhosis[J]. Liver Transpl, 2021, 27(12): 1711-1722. DOI: 10.1002/lt.26100.
[45]SchleicherEM, KremerWM, KalampokaV, et al. Frailty as tested by the clinical frailty scale Is a risk factor for hepatorenal syndrome in patients with liver cirrhosis[J]. Clin Transl Gastroenterol, 2022, 13(7): e00512. DOI: 10.14309/ctg.0000000000000512.
[46]XuCQ, MohamadY, KappusMR, et al. The relationship between frailty and cirrhosis etiology: from the functional assessment in liver transplantation (FrAILT) study[J]. Liver Int, 2021, 41(10): 2467-2473. DOI: 10.1111/liv.15006.
[47]LaiJC, RahimiRS, VernaEC, et al. Frailty associated with waitlist mortality independent of ascites and hepatic encephalopathy in a multicenter study[J]. Gastroenterology, 2019, 156(6): 1675-1682. DOI: 10.1053/j.gastro.2019.01.028.
[48]MullerX, MarconF, SapisochinG, et al. Defining benchmarks in liver transplantation: a multicenter outcome analysis determining best achievable results[J]. Ann Surg, 2018, 267(3): 419-425. DOI: 10.1097/sla.0000000000002477.
[49]SiramolpiwatS, KiattikunratK, SoontararatpongR, et al. Frailty as tested by the liver frailty index is associated with decompensation and unplanned hospitalization in patients with compensated cirrhosis[J]. Scand J Gastroenterol, 2021, 56(10): 1210-1219. DOI: 10.1080/00365521.2021.1957497.
[50]ShahS, GoldbergDS, KaplanDE, et al. Patient frailty is independently associated with the risk of hospitalization for acute-on-chronic liver failure[J]. Liver Transpl, 2021, 27(1): 16-26. DOI: 10.1002/lt.25896.
[51]SalimTI, NestlerodeLC, LucatortoEL, et al. Frailty as tested by gait speed is a risk factor for liver transplant respiratory complications[J]. Am J Gastroenterol, 2020, 115(6): 859-866. DOI: 10.14309/ajg.0000000000000609.
[52]SinclairM, PoltavskiyE, DodgeJL, et al. Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist[J]. World J Gastroenterol, 2017, 23(5): 899-905. DOI: 10.3748/wjg.v23.i5.899.
[53]DunnMA, JosbenoDA, TevarAD, et al. Frailty as tested by gait Speed is an Independent Risk Factor for Cirrhosis Complications that require hospitalization[J]. Am J Gastroenterol, 2016, 111(12): 1768-1775. DOI: 10.1038/ajg.2016.336.
[54]LaiJC, ShuiAM, Duarte-RojoA, et al. Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study[J]. Hepatology, 2022, 75(6): 1471-1479. DOI: 10.1002/hep.32268.
[55]LaiJC, DodgeJL, KappusMR, et al. Changes in frailty are associated with waitlist mortality in patients with cirrhosis[J]. J Hepatol, 2020, 73(3): 575-581. DOI: 10.1016/j.jhep.2020.03.029.
[56]DengLX, BischoffKE, KentDS, et al. Frailty is strongly associated with self-reported symptom burden among patients with cirrhosis[J]. Eur J Gastroenterol Hepatol, 2021, 33(1SSuppl 1): e395-e400. DOI: 10.1097/meg.0000000000002113.
[57]RockwoodK. Conceptual models of frailty: accumulation of deficits[J]. Can J Cardiol, 2016, 32(9): 1046-1050. DOI: 10.1016/j.cjca.2016.03.020.
[58]ArtruF, MiquetX, AzahafM, et al. Consequences of TIPSS placement on the body composition of patients with cirrhosis and severe portal hypertension: a large retrospective CT-based surveillance[J]. Aliment Pharmacol Ther, 2020, 52(9): 1516-1526. DOI: 10.1111/apt.16080.
[59]LaiJC, SegevDL, MccullochCE, et al. Physical frailty after liver transplantation[J]. Am J Transplant, 2018.18(8): 1986-1994. DOI: 10.1111/ajt.14675.
[60]MaharshiS, SharmaBC, SachdevaS, et al. Efficacy of nutritional therapy for patients with cirrhosis and minimal hepatic encephalopathy in a randomized Trial[J]. Clin Gastroenterol Hepatol, 2016, 14(3): 454-460.e3;quiz e33. DOI: 10.1016/j.cgh.2015.09.028.
[61]MeenaBL, TanejaS, TandonP, et al. Home-based intensive nutrition therapy improves frailty and sarcopenia in patients with decompensated cirrhosis: a randomized clinical trial[J]. J Gastroenterol Hepatol, 2023, 38(2): 210-218. DOI: 10.1111/jgh.16035.
[62]KonstantisG, PourzitakiC, ChourdakisM, et al. Efficacy of branched chain amino acids supplementation in liver cirrhosis: a systematic review and meta-analysis[J]. Clin Nutr, 2022, 41(6): 1171-1190. DOI: 10.1016/j.clnu.2022.03.027.
[63]ParkJG, TakWY, ParkSY, et al. Effects of branched-chain amino acid (BCAA) supplementation on the progression of advanced liver disease: a korean nationwide, multicenter, prospective, observational, cohort study[J]. Nutrients, 2020, 12(5): 1429. DOI: 10.3390/nu12051429.