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This is Scientific American — 60-Second Science. I'm Christopher Intagliata.
LSD
is one of the most potent hallucinogenic drugs—active at just around
100 micrograms...a miniscule amount. That fact has fascinated
pharmacologists for decades. Namely, how can it have such long-lasting
effects...12 hours or more...at such tiny doses?
To find out,
researchers legally obtained LSD. And built copies of the receptors it
binds to in the brain—serotonin receptors. They mixed the LSD and the
receptors together, and crystallized the result. They then imaged the
structure, using x-ray crystallography.
And they found that when LSD
linked up