人祸！巴西变异株的肆虐可能无关病毒突变；老师戴口罩，学生的感染风险降低多少？本周还有这些新冠研究新进...

正文

请到「今天看啥」查看全文

［关键信息］ 康复者血浆无法提高患者存活率。

Lancet : 11,558 COVID-19 patients were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1,399 (24%) of 5,795 patients in the convalescent plasma group and 1,408 (24%) of 5,763 patients in the usual care group died within 28 days. <14 May>

[key info] Convalescent plasma did not improve the survival rate of patients.

[link]

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00897-7/fulltext

4. 病毒学论坛： 因含大量突变，最初在巴西发现的 P.1 变异株被认为传染性更强。一种 P.1 始祖病毒携带一半 P.1 谱系特性的突变，包括位于 S 蛋白受体结合结构域的突变，在 P.1 及其相关谱系出现前就已隐秘传播数月。尽管 P.1 始祖病毒和同期 P.1 相关谱系均显示出 S 蛋白的关键突变，但它们的传播性均不及 P.1 。这表明，P.1 的大肆传播可能由病毒突变以外的因素所致，最有可能与人类行为有关。 （ 5 月 16 日）

［关键信息］ P.1 的大肆传播或由人类行为所致。

Virological: The P.1 variant first identified in Brazil was thought to be more infectious due to its large number of mutations. A P.1-ancestor carrying half of the P.1-lineage-defining mutations, including those at the RBD of the S protein, circulates cryptically for several months before the emergence of P.1 and P.1-related lineages. Although the P.1-ancestor and the contemporaneous P.1-related lineages displayed the key mutations in the S protein, none of them was so efficiently spread as P.1. This suggests that factors other than viral mutations, most likely related to human behavior, might have played a role in the remarkable dissemination of P.1. <16 May>

[key info] Human behavior might have led to the remarkable dissemination of P.1.

[link]

https://virological.org/t/identification-of-sars-cov-2-p-1-related-lineages-in-brazil-provides-new-insights-about-the-mechanisms-of-emergence-of-variants-of-concern/694

5. 《自然》： 研究人员将新冠病毒与辉瑞—拜恩泰科或莫德纳疫苗接种者的含大量抗体的血清混合。数据显示，接种疫苗产生的抗体抵御 B.1.617.1 变异株的有效性是中和疫情初期流行毒株的有效性的七分之一，但这些抗体在某种程度上仍能中和 B.1.617.1 变异株。 （ 5 月 17 日）

［关键信息］ 接种疫苗产生的抗体抵御 B.1.617.1 变异株的有效性是中和疫情初期流行毒株的有效性的七分之一。

Nature : Researchers combined SARS-CoV-2 with antibody-laden blood serum from people who had received either the Pfizer/BioNTech vaccine or that made by Moderna. Data show that antibodies generated by vaccination are seven times less effective at blocking B.1.617.1 than neutralizing the coronavirus strain that circulated early in the pandemic. But these antibodies were able to neutralize B.1.617.1 to some extent. <17 May>

请到「今天看啥」查看全文